اثريك دوره تمرينات‌مقاومتي و استقامتي هوازي منتخب روي بيانmir-26، mir-27b و برخي نشانگر بيوشيميايي و فيزيولوژيكي در زنان داراي اضافه‌وزن و‌ چاق

miRNA-26 , miRNA-27b , obesity an‎d overweight , exercise training

The Effect of a Course of Resistance an‎d Endurance Aerobic Exercises on Mir-27b, Mir-26b Expression an‎d some Biochemical an‎d Physiological Biomarkers in Women with Overweight/Oesity

فيزيولوژي ورزش

Background an‎d Objective: In recent years, the preva‎lence of obesity an‎d metabolic diseases caused by obesity has been increasing. Nowadays, microRNAs have been considered as useful clinical tools for identifying an‎d preventing important non-communicable diseases, including obesity. The overall aim of the present study was to investigate the effect of a selec‎ted resistance an‎d aerobic endurance training course on the expression of mir-26, mir-27b, an‎d some biochemical an‎d physiological markers in overweight an‎d obese women. Materials an‎d Methods: The present study was a quasi-experimental study with a pre-test-post-test experimental design, which was conducted in a field setting. Twenty-four overweight an‎d obese women aged 24-50years were ran‎domly selec‎ted an‎d matched in two groups: Resistance training (n=12; weight: 72.74±13.9 kg, height: 168.46±8.87 cm, an‎d body mass index: 31.27±3.3 kg/m2) an‎d selec‎ted resistance training (n=12; weight: 75.15±11.9 kg, Height: 170.01±8.1 cm, an‎d body mass index: 29.26±3.4 kg/m2). The experimental groups performed three sessions of selec‎ted aerobic resistance an‎d endurance training per week for 8 weeks. Real-time PCR was used to extract miRNA-mir-27b an‎d miRNA-26 from blood serum, an‎d ELISA was used to measure lipid profiles an‎d C-reactive protein. Cardiovascular endurance, shoulder girdle muscle strength an‎d endurance, wrist strength, an‎d body fat percentage were measured using validated tools an‎d methods. Paired t-test was used for intra-group comparisons before an‎d after the test, an‎d analysis of covariance was used for comparisons between groups at the p≤0.05 level. Results: Statistical analysis of the data indicated that there were significant between-group differences in miRNA-26 levels (p=0.001), an‎d also significant within-group differences compared to baseline (Resistance -5.4% vs. aerobic endurance, -5.6%; p≤0.05). No significant between-group differences were observed in miRNA-27 (p=0.473), but there were significant within-group differences compared to baseline (Resistance -6.6% vs. Aerobic endurance, -5.9%; p≤0.01) in the experimental groups. Also, no significant between-group changes were observed in LDL, HDL, an‎d total cholesterol levels, but significant differences were observed between the levels of triglycerides an‎d C-reactive protein in the experimental groups (p≤0.05). There were significant between-group differences in cardiovascular endurance (p≤0.05). On the other han‎d, significant within-group differences were observed compared to baseline (Resistance training 12.9% vs. Aerobic endurance, 9.3%; p≤0.01). Although no significant between-group differences were observed in wrist strength (p≤0.05), there were significant within-group differences compared to baseline in the resistance training group (Resistance 20.9% vs. Aerobic endurance, 8.8%; p=0.001). Conclusion: It seems that both resistance an‎d selec‎ted aerobic endurance training significantly improve the measured variables. selec‎ted resistance training showed the same effectiveness as aerobic endurance training an‎d therefore these training methods can be an appropriate training method in overweight an‎d obese women.

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