طراحي و سنتز سيستم رهايش نوين داروهاي آنتا گونيستي گياهي جهت كاربرد در درمان بيماري¬هاي ميگرن حاد و مزمن بر پايه استفاده از فيلم هاي چسبنده به مخاط

Design an‎d synthesis of a new release system of herbal antagonistic drugs for use in the treatment of acute an‎d chronic migraine diseases based on the use of sticky mucous films

مهندسي پزشكي

One of the requirements an‎d characteristics of todayʹs modern an‎d machine lifestyle is the increase in stress an‎d the spread of the epidemic of diseases related to the nervous system such as chronic headaches an‎d migraines. For this purpose, it was decided to use a new, easy, patient-friendly method to increase the effectiveness of Tanastom extract for the treatment of migraine. The most effective therapeutic effect of oral medications for migraine is lost in liver metabolism. In this drug release method, the film sticks directly to the mucous membrane of the cheek an‎d the drug absorption process takes place through the many capillaries inside the mucous tissue, on the other han‎d, because chemical drugs from the triptan group are very toxic an‎d have restrictions on the use of herbal extracts. Thanostomy was used. The effective ingredient of this extract is parthenolide, which acts like the rhizotriptan family an‎d is useful in the treatment of migraine. Hydroxypropyl methyl cellulose, polyvinyl alcohol, polyethylene glycol an‎d ethyl cellulose polymers with different weights (mg) were used in the preparation of these films by solvent casting method. 3 ml of Tanastom extract was loaded on each film. Films F1, F5, F6 had a uniform appearance an‎d good flexibility. They had the ability to load herbal medicine. The tests were performed on these three samples. The identification of the active ingredient of parthenolide in the extract was confirmed by FTIR test on all three samples. Surface morphology was analyzed by scanning electron microscope. The thickness of the films was from 0.2 to 0.4 mm. The drug release test was performed in vitro an‎d was confirmed for all three samples. Tensile strength test was done. In the results of these tests, the sample containing ethyl cellulose polymer was more favorable. The optimal effectiveness of the drug in the treatment of migraine was performed with a cell test in the F5, F6 film sample in the extra-corporeal environment. The films had high viability at a concentration of 25 μg/ml. The drug at a concentration of 0.5 μg/ml was favorable for survival. The result of the nitric oxide test showed a reduction in inflammation in the film an‎d parthenolide solution by 54% an‎d in the parthenolide sample by 78%.

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