تهيه هيدروژل هوشمند بر پايه پكتين و بررسي عملكرد آن در زمينه دارورساني وكشاورزي

Preparation of smart hydrogel based on pectin an‎d eva‎luation of its performance in drug delivery an‎d agriculture

شيمي آلي و پليمر

The development of targeted drug delivery systems with controlled release can increase the effectiveness of treatment an‎d reduce side effects. Hydrogels are a suitable option for this purpose due to their network structure an‎d sensitivity to environmental changes. In this study, two types of pH-sensitive polymer hydrogels were synthesized for use in targeted drug delivery. In the first part, a hydrogel based on pectin polymer containing chitosan nanoparticles was prepared as a carrier for the insulin drug. Physical, chemical, an‎d rheological tests showed that this hydrogel has a uniform structure, appropriate porosity, an‎d desirable viscoelastic behavior. Swelling an‎d gel fraction studies also showed that the hydrogel is stable in an acidic environment an‎d protects insulin, but swells in an alkaline environment an‎d releases the drug in a controlled manner. In the second part, to reduce the gastrointestinal side effects of naproxen, a hydrogel was synthesized through the cross-linking polymerization of acrylic acid based on chitin polymer an‎d polyvinyl alcohol. The drug naproxen was loaded into it, an‎d its structure, morphology, an‎d viscoelastic properties were eva‎luated through various tests. The results of structural an‎d rheological tests showed that this hydrogel has good mechanical stability an‎d protects the drug in a simulated gastric environment. The drug release eva‎luation in a simulated intestinal environment showed that about 69% of naproxen was released gradually, which indicates the high efficiency of the system in targeted an‎d controlled drug release. Overall, the results of these two sections showed that pH-sensitive hydrogels can play an effective role as smart an‎d non-invasive carriers in improving the effectiveness of sensitive drugs such as insulin an‎d drugs with gastrointestinal side effects such as naproxen. Also, in this study, due to the significant water absorption capacity of pectin-based hydrogel, its performance as a superabsorbent in the agricultural field was eva‎luated. The results of the absorption capacity of distilled water (about 1200 g/g), salt water (about 100 g/g), an‎d rainwater (about 900 g/g) indicate the potential of this hydrogel for use in agricultural applications.

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