سنتز تك مرحله‌اي بنزايميدازول‌ها از الكل‌ها با استفاده از كاتاليست چارچوب فلز آلي (MOF) بر پايه اتصال‌دهنده H6TDPAT

In this study, a novel nickel-based metal–organic framework (MOF) catalyst was designed an‎d synthesized using the multidentate linker H₆TDPAT. The primary objective was to develop a stable, efficient, an‎d recyclable catalytic system for facilitating organic transformations under mild an‎d environmentally friendly conditions. The catalyst was synthesized through a controlled procedure an‎d characterized using various analytical techniques including FTIR, XRD, SEM, BET, an‎d Elemental mapping. The results confirmed its porous structure, high surface area, uniform dispersion of active nickel sites, an‎d excellent thermal an‎d chemical stability. The catalytic performance of the synthesized MOF was eva‎luated in the one-pot synthesis of benzimidazole derivatives from various benzyl alcohols an‎d 1,2-phenylenediamine. Benzimidazoles are nitrogen-containing heterocycles with significant importance in medicinal chemistry due to their wide range of biological activities, including anticancer, antiviral, an‎d anti-inflammatory properties. Developing efficient an‎d sustainable synthetic routes for these compounds remains a key challenge in organic synthesis. The reactions were carried out in aqueous media using tetrabutylphosphonium bromide as a green ionic liquid, yielding products with high efficiency an‎d selec‎tivity. Furthermore, the catalyst demonstrated excellent reusability over eight consecutive cycles with minimal loss in activity, highlighting its structural robustness an‎d practical applicability. This study, for the first time, demonstrates that the use of a nickel-based metal–organic framework catalyst incorporating the multidentate linker H₆TDPAT, in combination with a green solvent an‎d ionic medium, can provide efficient an‎d sustainable synthetic pathways for the production of heterocyclic compounds, representing a significant step toward the advancement of green technologies in organic chemistry.

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