بررسي اثر تزريق صفاقي محيط شرطي سلول هاي بنيادي مزانشيمي با ورزش هوازي بر بهبودي پس از انفاركتوس حاد ميوكاردي در رت

Myocardial infarction (MI) remains one of the leading causes of heart failure an‎d mortality worldwide. Recent studies have demonstrated that mesenchymal stem cells (MSCs) an‎d their secreted products—known as conditioned medium (CM)—can exert significant therapeutic effects on cardiac repair following ischemic injury. In parallel, aerobic exercise has been recognized as an effective non-pharmacological intervention that contributes to cardiac rehabilitation through modulation of inflammatory markers, improvement of ventricular performance, enhancement of angiogenesis, an‎d reduction of fibrosis. Methods: This experimental study aimed to eva‎luate the effects of intraperitoneal administration of MSC-conditioned medium, in combination with aerobic exercise, on cardiac functional parameters in rats with induced acute myocardial infarction. Male Wistar rats were ran‎domly divided into five groups after MI induction. The interventions, including MSC-CM injection, aerobic training, an‎d their combination, were applied for eight weeks. At the end of the protocol, several indices were assessed, including infarct size, myocardial fibrosis, angiogenesis rate, left ventricular functional parameters (LVIDd, LVIDs, FS%), an‎d inflammatory markers such as TNF-α. Results: The combined treatment group (MSC-CM + exercise) showed significantly greater improvements in cardiac performance, reduced myocardial fibrosis, enhanced angiogenesis, lower mortality, an‎d suppression of inflammatory responses compared with other groups. Conclusion: These findings suggest that the synergistic interaction between mesenchymal stem cell–derived conditioned medium an‎d aerobic exercise may serve as a novel an‎d effective therapeutic approach for cardiac rehabilitation following myocardial infarction.

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