سنتز و مشخصه‌يابي نانوذرات فريت نيكل براي كاربرد در تصوير برداري MRI به‌عنوان عامل كنتراست دوگانه

Synthesis an‎d characterization of nickel ferrite nanoparticles for use in MRI imaging as a dual contrast agent

نانو فناوري

Abstract Magnetic nanoparticles (MNPs) have attracted widespread attention in biomedical fields, including magnetic resonance imaging (MRI), due to their unique properties. Among them, nickel ferrite (NiFe2O4) is considered as a potential can‎didate for use as an MRI contrast agent due to its soft magnetic properties, high saturation magnetization, coercivity, an‎d suitable chemical stability. This study focuses on the synthesis, characterization, an‎d eva‎luation of the imaging performance of nickel ferrite nanoparticles with the ability to provide T1 an‎d T2 contrasts. In this study, nickel ferrite nanoparticles were produced by hydrothermal method according to the optimal conditions obtained from previous studies at 180°C an‎d pH=10 with different synthesis times. Also, by changing the synthesis conditions an‎d using different precursors, the particle morphology changed from spherical to cubic.Field emission Scanning electron microscopy (FE-SEM) images showed the average particle size for the six samples synthesized at different times, ranging from 10 to 50 nm. X-ray diffraction (XRD) confirmed that the spinel crystal structure of pure nickel ferrite was obtained at synthesis different times. Also, vibrational sample magnetization (VSM) showed saturation magnetization between 38 an‎d 64 emu / g. To investigate the contrast efficiency, uncoated an‎d PEG-coated nickel ferrite samples were eva‎luated by MRI imaging, which showed good T2 contrast an‎d lower T1. The results showed that the sample synthesized at 12 hours performed best an‎d provided good image contrast in T1 an‎d T2 images. The cubic sample showed good T2 contrast an‎d lower T1 contrast. Also, the stability test showed that these nanoparticles were stable for at least one week after synthesis.Overall, this study demonstrated that nickel ferrite nanoparticles with controlled changes in synthesis conditions can be used as dual MRI contrast agents. Further optimization of surface coating an‎d composition tuning could lead to further improvement of the performance of these nanoparticles in medical imaging Keywords: Nickel ferrite nanoparticles, MRI, contrast agent, hydrothermal synthesis, magnetic characterization

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