مقايسه اثر يك دوره تمرينات مقاومتي با EMS بر بيان ژن ميونكتين،‌‌ فاكتور رشد فيبروبلاست 21، آيريزين و سطوح فاكتور رشد شبه انسولين 1 و انسولين در مردان داراي اضافه وزن

Comparison of the effect of a period of resistance training with EMS on the expression of myonectin, fibroblast growth factor 21, irisin, an‎d levels of insulin-like growth factor 1 an‎d insulin in overweight men

فيزيولوژي ورزش

Abstract Objectives: Overweight an‎d obesity can be a factor in the occurrence of many common diseases an‎d cause disruption in the secretion an‎d function of myokines an‎d also increase insulin resistance. The aim of this study was to compare the effect of a course of resistance training with EMS on the expression of myonectin, fibroblast growth factor 21, irisin an‎d insulin-like growth factor 1 an‎d insulin levels in overweight men. Materials an‎d Methods: The present study was a quasi-experimental study with a pre-test-post-test design with a control group. The sample of the present study consisted of 45 overweight men with a mean body mass index of 28.9±2.09 (kg/m2) an‎d a mean age of 41.73±5.08 (years) based on the inclusion criteria.The subjects were ran‎domly divided into 3 groups: EMS training (n=15), resistance training (n=15), an‎d control (n=15). The training course was conducted for 12 weeks an‎d 3 sessions per week, each session lasting 40 minutes. The resistance group performed exercises at an intensity of 50 to 85% of one repetition maximum, an‎d the EMS group performed exercises at an intensity of 70 to 85% (85 Hz, 350 μs, pulse duration of 4 seconds, 2 seconds rest). In each exercise session, each group performed the exercise movements in three sets with 12 to 15 repetitions per set. Fasting blood samples were taken from the subjects 48 hours before the first exercise session an‎d 48 hours after the last exercise session to measure the levels of myonectin, irisin, FGF21, IGF-1, an‎d insulin. Plasma IGF-1 an‎d insulin were measured by ELISA, an‎d myonectin, irisin, an‎d FGF21 gene expression was measured by Real Time PCR. Insulin resistance was also calculated based on the HOMA-IR formula. Body composition an‎d anthropometric variables were measured using a body composition device, model 356-X. Contact was measured. After implementing the necessary assumptions, statistical analysis was performed through one-way variance test with Tukeyʹs post hoc test an‎d covariance with Bonferroni post hoc test an‎d paired t-test with SPSS version 24 software at a significance level of less than 0.05. Results: The results of the study showed that there was a significant difference between the mean gene expression of myonectin (P=0.001), irisin (0.001), IGF-1 (P=0.001), FGF21 (P=0.003) an‎d insulin, glucose an‎d insulin resistance (P=0.001) in the control, resistance training an‎d EMS groups. The changes in myonectin, irisin, IGF-1 an‎d FGF21 were increasing an‎d insulin, glucose an‎d insulin resistance were decreasing. Conclusion: According to the results obtained, in both groups, an increase in myonectin levels, Irisin, FGF21, IGF-1 an‎d improved insulin resistance levels an‎d body composition in overweight men were observed. Overall, given the positive results of EMS, it seems likely that this new training style can be used alongside other training methods in exercise programs. Keywords: Resistance training, EMS, Myonectin, Irisin, Fibroblast growth factor 21, Insulin-like growth factor 1, Insulin

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