نانوذرات آبي پروس متخلخل توخالي بارگذاري شده با نقاط كربني حساس به pH به عنوان يك عامل تشخيصي درماني چند منظوره

Hollow Mesoporous Prussian Blue Nanoparticles for In Vivo Synergistic Chemo-Photothermal Cancer Therapy an‎d Dual-Mode Magnetic Resonance/Fluorescence Imaging

شيمي تجزيه

Abstract Integrating multiple diagnostic an‎d therapeutic modalities into a single system is a promising novel approach for effective cancer treatment; however, it still faces challenges. In this study, a smart an‎d multifunctional nanosystem was designed capable of simultaneous diagnosis an‎d synergistic chemo-photothermal therapy of tumors, guided by MRI an‎d fluorescence imaging. By employing a pH-responsive strategy, gadolinium-doped carbon quantum dots (GCDs) an‎d doxorubicin (DOX) were encapsulated in hollow porous Prussian blue nanoparticles (HMPB NPs). HMPB NPs with an average diameter of 79 ± 31 nm an‎d a hydrodynamic size of 249 ± 25 nm exhibited desirable physicochemical properties. Results showed that DOX release increased from 5.6% at pH 7.4 to 31.5% at pH 5.0. Furthermore, the release of GCDs increased by 30.4% with decreasing pH. The r1 relaxivity rate in acidic environments also increased from 5.2 mM-1s-1 to 8.6 mM-1s-1. Additionally, HMPB NPs exhibited excellent photothermal conversion properties, an‎d in vivo studies showed that this nanosystem was capable of increasing tumor temperature to over 50 °C under near-infrared laser irradiation. Moreover, MRI imaging studies showed that the tumor MRI signal intensity increased from 95 ± 8 au to 299 ± 9 au after nanosystem administration, indicating a more than threefold increase in tumor contrast. This nanosystem, by combining chemotherapy, photothermal therapy, an‎d dual imaging, has high potential for effective tumor diagnosis an‎d treatment. However, to fully eva‎luate the clinical potential of this nanosystem, more extensive studies an‎d clinical trials are necessary. Keywords: Cancer, Hollow mesoporous Prussian blue, Gadolinium-doped carbon quantum dots, Theranostic, Combined imaging, Chemo-photothermal therapy.

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