مقايسه تاثير ورزش در دورانهاي مختلف (اوايل زندگي و بزرگسالي ) بر بيماري آلزايمر القا شده توسط آلومينيوم كلرايد در رت

Comparison of the effect of exercise in different periods (early life an‎d adulthood) on Alzheimerʹs disease induced by aluminum chloride in rat

زيست شناسي گياهي و جانوري

Abstract The present study aimed to investigate the comparative effects of exercise during early life an‎d adulthood on preventing effect of aluminum chloride-induced Alzheimerʹs in rats. The groups included: (1) Saline group, (2) Aluminum chloride-receiving group, (3) Aluminum chloride-receiving + adult exercise group, (4) Aluminum chloride-receiving + early life exercise group, an‎d (5) Saline + early life exercise group. The aluminum chloride an‎d saline groups received injections via gavage for 2 months. The exercise protocol involved treadmill exercise for 2 months an‎d 5 days per week. During the first month, rats exercised for 30 minutes at 0% incline an‎d a speed of 12 meters per minute, the duration an‎d speed increased in the second month to 1 hour at 0% incline. At the end of the exercise an‎d drug administration period, the groups were eva‎luated using behavioral tests (Morris water maze an‎d shuttle box). The results showed that aluminum chloride caused impairment in spatial an‎d passive avoidance memory an‎d led to neurodegeneration an‎d neuron shrinkage. Exercise during early life an‎d adulthood prevented the impairment caused by aluminum chloride in spatial an‎d passive avoidance memory in adulthood. Exercise during early life also prevented neurodegeneration an‎d neuron shrinkage induced by aluminum chloride in adulthood. However, neuron shrinkage was observed in some neurons in the exercise during adulthood group. The saline + early life exercise group showed significant differences in some behavioral test factors compared to the saline group, an‎d histologically, differences were also observed between these groups. Keywords: Alzheimerʹs disease, Exercise, Aluminum chloride, Rat, Early life, Adulthood, Memory.

5 فصل