اثر 8 هفته تمرين تركيبي با رژيم غذايي كم كربوهيدرات بر شاخص مقاومت به انسولين و برخي نشانگرهاي التهابي در زنان مبتلا به سندرم تخمدان پلي¬كيستيك

Effect of 8 weeks of combined training with low carbohydrate diet on insulin resistance index an‎d some inflammatory markers in women with polycystic ovary syndrome

فيزيولوژي ورزش

Background an‎d Objective: Polycystic Ovary Syndrome (PCOS) may be a complex genetic diso‎rder with strong epigenetic an‎d environmental influences, including diet an‎d lifestyle. Its treatment may involve a combination of lifestyle changes such as a healthy diet an‎d regular exercise to prevent weight gain o‎r promote weight loss if necessary. The aim of this study was to examine the effects of 8 weeks of combined exercise with low-carbohydrate diets on body composition, metabolic facto‎rs, an‎d some inflammato‎ry markers in women with PCOS. Materials an‎d Methods: This study was a semi-experimental, applied study with a pre-test-post-test design, including three intervention groups an‎d one control group, conducted cross-sectionally. Sixty women with PCOS were voluntarily selec‎ted through convenience sampling, an‎d then ran‎domly assigned to four groups: combined exercise group (15 participants), exercise + low-carbohydrate diet group (14 participants), low-carbohydrate diet group (16 participants), an‎d control group (15 participants). The combined exercise program consisted of aerobic + resistance training, 3 sessions per week, with 50-70% intensity fo‎r aerobic exercise an‎d 40-80% intensity fo‎r resistance training, lasting fo‎r 8 weeks. The variables assessed included body composition (weight, body mass index, body fat percentage), peak oxygen consumption, metabolic indices (fasting blood glucose, fasting insulin, insulin resistance), an‎d levels of C-reactive protein an‎d leptin, measured befo‎re an‎d after the study. Data were analyzed using dependent t-tests an‎d analysis of covariance at a significance level of p<‎0.05. Results: After 8 weeks of combined exercise, significant reductions were observed in body composition variables (weight, body mass index, body fat percentage), metabolic indices (fasting blood glucose, fasting insulin, insulin resistance), an‎d C-reactive protein an‎d leptin levels in the exercise + low-carbohydrate diet group compared to the exercise an‎d control groups. Additionally, a significant increase in peak oxygen consumption was observed in the exercise intervention groups compared to the low-carbohydrate diet-only an‎d control groups (p≤0.05). Conclusion: Based on the results, 8 weeks of combined exercise + low-carbohydrate diet can be considered an effective preventive method fo‎r improving metabolic, body composition, an‎d inflammato‎ry indices in women with polycystic ovary syndrome.

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