مقايسه اثر دو شيوه تمريني منتخب روي نيمرخ ليپيدي و تغييرات درسطوح miRNA 192a وmiRNA 122 در زنان داراي اضافه وزن و چاق

Background and purpose: In recent years, the preva‎lence of overweight/ obesity have been increased. Today, microRNAs are considered as useful clinical tools for the detection and prevention of important non-communicable diseases. The purpose of this study was to compare the effect of two selected resistance and combined training on miRNA-122 & miRNA-192a expression and some biomarkers of obesity in women with overweight / obesity. Methods: This research was a semi-experimental with a pre-test-post-test design that was conducted in the field. The number of 24 overweight and obese women aged 20-45 years in two groups of resistance training (n=10; weight: 74.72±13.93 kg, height 168.46±8.87 cm and body mass index 31.27±3.3 kg/m2), selected resistance training were selected as available and matched in two groups. Participants engaged in 8-week exercise training, 3 sessions/week. The extraction of miR-192-a & microRNA-122 was performed by the RT-PCR system. The lipid profile and glucose levels have been assessed by Luminescence electro-chemical methods. The cardiovascular endurance, strength and endurance of shoulder girdle muscles, the strength and endurance of the abdominal muscles, and body fat percentage of subjects were assessed by valid procedures. Correlated t-test was used for pre-post-test intra-group comparison, and analysis of covariance statistics were used for between group comparisons. A priori, the level of significance was set at 0.05. Results: The statistical analysis of the data indicates that there were no significant between-group differences in the levels of miRNA-122 (Resistance 34.9% vs. combined, 36.7%; p=0.871) and miRNA-192a (Resistance 5.7% vs Combined 9.9% (p=0.879) in the experimental groups. Also, changes in the levels of LDL (Resistant 0.82% vs. combined, 9.0%; p=0.069), Triglyceride (Resistant 21.66% vs. Combined, 19.55%; p=0.334), Fasting blood sugar (Resistance 7.25% vs. Combined, 5.93%; p=0.647), Cholesterol (Resistance 5.91% vs. Combined, 12.14%; p=0.201), Hand grip strength (Resistance 18.32% vs. Combination, 15.05%; p=0.474), and cardiovascular endurance values (Resistance training 5.34% vs. combined, 5.04%; p=0.610) was not significant. On the other hand, there was a significant increase in HDL (Resistant 18.91% vs. Combined, 17.53%; p=0.014), strength and endurance of shoulder girdle muscles (Resistance 93.9% vs. combination, 136.36%; p=0.002) and the strength and endurance of the abdominal muscles (Resistance 97.76% vs. combined, 188.57%; p=0.051), and significant decrease in body fat percentage (Resistance training -2.41% vs. Combined, -3.61 %; p=0.024) of subjects of different groups. Conclusions: It seems that both resistance and combined training protocols have identical effectiveness to improve the levels of measured variables women with overweight /obesity. Given that it is suggested that this type of exercises could be used optimally.

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